I have written this post many years ago .
" Concrete Evidence for Phage Therapy
Wednesday, 25 November 2009
"A controlled clinical trial of a therapeutic
bacteriophage preparation in chronic otitis
due to antibiotic-resistant Pseudomonas aeruginosa;a preliminary report of efficacy"
UCL Ear Institute and Royal National Throat, Nose and Ear Hospital, Grays Inn Road, London, and Biocontrol Limited, BioCity, Pennyfoot Street, Nottingham, UK Clin. Otolaryngol. 2009, 34, 349–357
The present controlled trial of bacteriophages indicates that this form of biological therapy has considerable promise.
Digital photography before (a) and after (b) in patient A0012.
Patient A0012 had a longstanding resistant otitis externa. There was swelling of the deep canal skin and ulceration in the roof of the canal adjacent to the tympanic membrane. By day 42 this had resolved and the patient was essentially symptom free"
What have happened to phage product Biophage-PA for the treatment of chronic inner ear infections and to phage product BioPhage-PR for the treatment of lung infections in cystic fibrosis patients?
BioVet-PA and BioPhage-PA from Biocontrol Limited
The first step is to collect the information about Biocontrol Limited company ( the link in the old post is not active).
By this document emerges that the main products were phages for Pseudomonas aeruginosa with a potential use in different clinical situations. Biocontrol Limited company is now a subsidary of AmpliPhi Biosciences Corporation.
Link
The treatment of chronic inner ear infections by phages in theory is more easy respect the treatment of lung infections in cystic fibrosis patients because the infection of the inner ear is an infection ouside the body and for that reason is the best situation for a lytic action by phages.
Why after 5 years (2009-2014) there are not others clinical evaluations on the field for this Phage cocktail (six phages) regarding the treatment of chronic inner ear infections ?
The inner ear is accessible to phages and this anatomical position is good because the obstacle presence to the action of phages is limited. Are there some reasons? One reason could be the biofilm presence that does not allow the action of phage cocktail.
From this web site there is the confirmation :
My objections:
Is necessary to render the biofilm pemeable to Phages before to start in the treatment of chronic inner ear infections by phage cocktail ?
Is a broad-spectrum phage cocktail impossible to prepare for this clinical patology because it is necessary to customize the cocktail for each patient like the document described above?
